Treatment Guideline for Depression/Depressive Disorders & Mood Disorders

Depression is a common and debilitating mood disorder.  More than just sadness in response to life’s struggles and setbacks, depression changes how you think, feel, and function in daily activities.  It can interfere with your ability to work, study, eat, sleep and enjoy life.  The feelings of helplessness, hopelessness, and worthlessness can be intense and unrelenting, with little, if any, relief.

While some people describe depression as “living in a black hole” or having feelings of impending doom, others feel lifeless, empty and apathetic.  Men, in particular, can feel angry and restless.  No matter how you experience depression, left untreated it can become a serious health condition.

This Treatment Guideline is to be used for cannabis oils that are endorsed by CannaMedica and is to be used as a guideline for the treatment of:

Major Depression Persistent Depressive Disorder
Bipolar Disorder Seasonal Affective Disorder
Psychotic Depression Peripartum (Postpartum) Depression
Premenstrual Dysphoric Disorder (PMDD) Situational Depression
Atypical Depression Clinical Depression


Our clients are people who have consistently chosen cannabis oil that has been endorsed by CannaMedica over conventional medicines that have let them down.  Nobody likes to get high, least of all when you are treating young children – if our oils are used correctly, this can be avoided completely.  Should you not feel comfortable or have any questions at any time, our trained staff are on standby to answer your concerns or questions.


Cannabis oils are best kept in a cool, dark environment.  Oils have a shelf-life of many years, but to avoid degradation, please keep away from direct light and heat.


For dosing when using a tincture, do not dilute in water or juice. All our oils are supplied in a dropper-top bottle for ease of dispensing.  Do not squeeze hard on the dropper bulb, but allow for gravitational dispensing of drops, while applying light pressure to the dropper bulb.  It is best dispensed directly into the mouth, but should you feel unsure, the drops can be dispensed onto a teaspoon to ensure accurate dosing.  CBD has a bitter taste and some people may find this unpleasant.  Should you feel uncomfortable with the taste, a small bit of honey on the teaspoon can assist.

IMPORTANT NOTE:  People who suffer from anxiety, depression and stress should NOT take oils with a high THC content.  Oils high in THC may have the opposite effect and cause you to become more anxious and/or paranoid.


CBD refers to cannabis oil with a high content ratio of CBD, which promotes general good health and wellbeing.  Cannabis oils with a high content of CBD are made from CBD-rich strains of cannabis and are not to be confused with hemp CBD, which has little to no therapeutic qualities and is a nutritional supplement.  CBD oil made from the cannabis plant contains a modicum of THC to render it effective.  In order for CBD to be at its most efficacious, it needs to work in synergy with THC, a phenomenon known as “The Entourage Effect”.   CBD is not psychoactive and is a natural and powerful anti-inflammatory agent which effectively treats the pain associated with inflammation.

CBD Cannabis Oils endorsed by CannaMedica are CHILD-FRIENDLY.


In addition to the myriad of therapeutic and medicinal qualities that you can expect from CBD oil, taken on its own, can effectively treat the following conditions:

·         General Health & Wellbeing ·         Depression ·         Anxiety
·         Stress ·         Hypertension (High Blood Pressure) ·         Diabetes
·         Cancer Prevention ·         Cancer Remission ·         Heart Disease


CannaMedica endorses CBD oil produced from a CBD-rich strain with a 20:1 ratio CBD to THC.


THCA is found in fresh, undried cannabis flowers.  People who suffer from anxiety, depression and stress should not take oils high in THC, which is why THCA is the recommended replacement.  Most people who suffer from depression require something that is uplifting and find that CBD alone is too subtle.  THCA is non-psychoactive and is more uplifting that CBD oil.


THCA has been shown to modulate the autonomic nervous system, the autoimmune system, and microcirculation. It is known to relieve pain due to inflammation and to have anti-convulsant, anti-spasmodic, and antioxidant properties. It is reported to be immune supportive and be ant proliferative (anticancer) however, clinical results are currently unavailable.


  • It is known to be used internally as a digestive, oils,
  • It may be used as a topical for sore muscles, bruising, insect bites, rashes, mild abrasions, and certain skin conditions,
  • It can be used in conjunction with other cannabinoids including THC, CBD and CBN.

Given that THCA is non-psychoactive, it can be metabolized in much larger doses than THC, making it an attractive option for medical users. Preliminary studies suggest THCA has strong anti-inflammatory properties and is especially helpful in managing the severe pain caused by inflammation in Lupus and arthritis patients.

Here are some of the potential benefits studies have started to unveil:

  • Anti-inflammatory properties for treatment of pain related ailments incl. arthritis and lupus,
  • Neuroprotective properties for treatment of neurodegenerative diseases,
  • Anti-emetic properties for treatment of nausea and appetite loss,
  • Anti-proliferative properties noted in studies of prostate cancer,
  • Has a more uplifting effect, and is preferable cannabinoid for treating depression.

Other possible medicinal avenues supported by patient stories include insomnia, muscle spasms, and pain. Unfortunately, we’ll have to wait for more studies to substantiate all of the above benefits before we can fully understand what THCA means for the future of cannabinoid-based medicines.

THCA oil is recommended as an optional treatment for general health & wellbeing, specifically as it is an uplifting cannabinoid, with the added benefit of assisting gut health.


Please note that for all the conditions listed above, CBD oil is usually sufficient and THC should only be added to complement if necessary.  Speak to our trained staff to find out which oils best suit your needs.

Using our tincture, we recommend starting with a dosage of:

  • CBD: 5-10 drops of CBD 3 times per day.
  • THCA: 3-5 drops 2-3 times per day

All tinctures contain 1000mg extract and are suspended in 10ml MCT oil as a carrier liquid.  Each bottle contains 500+ drops and is supplied in a dropper-top bottle.  Each drop of tincture is equal to 2mg of cannabis extract.

CannaMedica is unable to comment on other cannabis oils, whose origins are unknown to us.  We recommend reading about Cannabis Oil in South Africa, before making any decisions.



All cannabis oils endorsed by CannaMedica are made from medical grade, organic cannabis flowers only.  The oils are processed in laboratory conditions using the latest technology.  Supercritical CO² extraction is the cleanest and least invasive extraction technique and is completely solvent-free.  The entire process, from soil to oil, is controlled – after all, what you put in is what you get out.  Our oils are not lab tested at local laboratories.


Every person’s tolerance levels vary.  Rather be safe and start with low dosages and increase until the desired effect is reached.  This way one avoids getting high altogether.  If too much THC or CBN is consumed too quickly, a “high” or “stoned” feeling can be experienced.  A general change in perception, euphoria (heightened mood) and an increase in appetite.  Short-term effects include a decrease in short-term memory, dry mouth, impaired motor skills, red eyes and feelings of paranoia and/or anxiety.  In the event of experiencing a “high”, it is best to lie down, take a nap and sleep it off.  The feeling will pass!


The information contained in this guideline is not intended nor implied to be a substitute for professional medical advice.  All information is provided for educational purposes only.  You assume full responsibility for how you choose to use this information.  Always seek the advice of your medical doctor or other healthcare providers before starting a new treatment or discontinuing an existing treatment.  Talk to your healthcare provider about any questions you may have regarding a medical condition.  Nothing contained herein is intended to be used for medical diagnosis or treatment.


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